(Oncovin, Vincristine sulfate, Vincasar PFS, Vincrex, Vincrisul)
of Drugs: alkaloids
Lilly and Company
on Patient Assistance program:
for Prescription Assistance -1-888-4PPA-NOW (1-888-477-2669)
A clear and colorless liquid with a slight vinegar-like odor.
It is given intravenously. It may also be given through a central
line which is inserted into a vein near the collarbone or by use
of a port. Dosage is adjusted for each patient since overdose is
Vincaleukoblastine, 22-oxo-, sulfate(1:1) (salt)
Vincristine, alone or in combination with other antineoplastic
medications, is used for many types of cancer including leukemia,
lymphoma, breast cancer, lung cancer, malignant melanoma, cancer
of the uterine cervix, colorectal cancer, and Wilms' tumor.
If you notice any stinging or burning around the vein while
the drug is being given, or any leakage of fluid from the injection
site tell the doctor or nurse.
the area around the injection site becomes red or swollen at any
time, even after treatment when you are home, you develop a fever,
chills or any unexplained bruising or bleeding, or feel ill, even
with a normal temperature, develop black, tarry stools or blood
in urine or stools, a cough or hoarseness, pinpoint red spots on
your skin get medical help immediately.
you are taking Probenecid (e.g., Benemid) or Sulfinpyrazone (e.g.,
Anturane) advise your doctor. Vincristine may increase the amount
of uric acid in the blood and the dosage on the other drugs that
lower uric acid may need to be adjusted. This may also cause gout
or kidney stones if you are susceptible. Discuss whether you need
to drink extra fluids to avoid kidney problems.
Effects: Vincristine’s major side effects are hair loss,
changes in the sense of taste and a reversible peripheral neuropathy
which may cause numbness or tingling in toes and fingers.
decrease in bone marrow function which reduces the number of platelets
can lead to bleeding, increased susceptibility to infection and
side effects may include nausea, constipation, stomach cramps, bed
wetting, decrease or increase in urination, difficult or painful
urination, lack of sweating, joint pain, lower back or side pain,
visual changes, dizziness, lightheadedness, difficulty controlling
muscle movement, drooping eyelids, headache, jaw pain, weakness,
leukopenia and inflammation of the mouth.
to Drug Index
information is intended as reference and not as medical advice.
All treatment decisions should be made with your team of medical
professionals and prescriptions must be given by your doctor.