(Filgrastim, Leukine, Granulocyte colony stimulating factor (G-CSF),
Sargramostim, Granulocyte-macrophage colony stimulating factor (GM-CSF))
of Drugs: Antineutropenic/Hematopoietic
Amgen - Filgrastim - Neupogen - G-CSF
Immunex - Sargramostim - Leukine - GM-CSF
(not commercially available in Canada)
on Patient Assistance program:
Amgen - Amgen SAFETY NET® Program for
NEUPOGEN, (800) 272-9376
Immunex Corporation - Patient Assistance Program - (800) 334-6273
- Contact: Gregg Bayles
Neopogen is a sterile‚ clear‚ colorless‚
preservative-free liquid administered by injection.
Filgrastim - Sargramostim
Hematopoietic stimulants have been
shown to be safe and effective in accelerating the recovery of neutrophil
counts following chemotherapy.
Filgrastim should be administered no earlier
than 24 hours after the administration of cytotoxic chemotherapy
and should not be administered in the period 24 hours before the
administration of chemotherapy.
is contraindicated in patients with known hypersensitivity to the
drug, E coli-derived proteins or any component of the product.
is a chance that conditions caused by inflammation or immune system
problems may be worsened by colony stimulating factor. Tell your
doctor if you have:
Heart disease--Risk of some unwanted effects (heart rhythm problems,
retaining water) may be increased
Kidney or Liver disease--May be worsened by colony stimulating factor
Lung disease--Colony stimulating factor may cause shortness of breath
You may experience bone pain of mild-to-moderate severity. This
can usually be controlled by non-narcotic analgesics.
The presence of other medical problems may affect the use of colony
stimulating factors. Make sure you tell your doctor if you have
any other medical problems, especially:
with your doctor as soon as possible if you notice any redness or
pain at the site of the injection, if you develop a fever, rapid
or irregular heartbeat, sores on skin or wheezing.
with your doctor as soon as possible if you notice any weakness,
redness or pain at the site of the injection, if you develop chest
pain, a fever, rapid or irregular heartbeat, shortness of breath
or wheezing, sores on your skin, swollen feet or lower legs, or
any sudden weight gain. let your doctor know if you feel dizziness
or faintness or flushing of your face after the first dose of medicine.
both filgrastim and sargramostim
with your doctor if you notice any headache, pain in arms or legs,
pain in joints or muscles, pain in lower back or pelvis, skin rash
side effects not listed above may also occur in some patients. If
you notice any other effects, check with your doctor.
to Drug Index
information is intended as reference and not as medical advice.
All treatment decisions should be made with your team of medical
professionals and prescriptions must be given by your doctor.