(CTX, CytoxanŽ, NeosarŽ,
Genoxal (Mexico), Ledoxina (Mexico), Procytox® (Canada)
of Drugs: Antineoplastic agents-immunosuppressant-Alkylating
Cyclophosphamide Tablets (Roxane
Laboratories Inc-Boehringer Ingelheim),
Cytoxan® ( Bristol-Myers Squibb Co - Mead Johnson and Co),
Neosar® (Pfizer - Pharmacia & Upjohn)
on Patient Assistance Program:
Partnership for Prescription Assistance -
Cytoxan® - Bristol-Myers Squibb Patient Assistance Foundation,
PO Box 1058
Somerville, NJ 8876
(http://www.bmspaf.org/ - Web Site is not currently available)
Neosar® - Pfizer
Helpful Answers, Pfizer
Patient Assistance Programs 1-866-776-3700
medication may be administered in tablet form, as an oral solution
or by injection.
Cyclophosphamide is used to treat cancer of the ovaries,
breast, blood and lymph system, nerves, retinoblastoma, multiple
myeloma, and mycosis fungoides. It is also used for treatment of
some kinds of kidney disease and other conditions as determined
by your doctor. Cyclophosphamide interferes with the reproductive
processes of cancer cells.
This medicine may cause birth defects if either the male or female
is taking it at the time of conception or if it is taken during
pregnancy. As with many cancer medicines, sterility occurs commonly
with cyclophosphamide, but is usually only temporary.
is a chance that this treatment will increase your risk for certain
types of cancer, such as leukemia or bladder cancer. Discuss these
possible effects with your doctor.
your doctor if you are using any of the following medications and
Cyclophosphamide has been prescribed:
may increase the side effects of these medicines or radiation therapy
on the blood. Inform your health care team if you are taking Amphotericin
B (Fungizone), any medication for overactive thyroid, Chloramphenicol
(Chloromycetin), Colchicine, Flucytosine (Ancobon), Ganciclovir
(Cytovene), Interferon (Intron A, Roferon-A), Methotrexate, Plicamycin
(Mithracin), Zidovudine (AZT, Retrovir), or have ever been treated
with radiation or other cancer medicines.
is a danger of increased risk of infection and development of cancer
if cyclophosphamide is used in combination with any of these drugs
that can impair the immune system: Azathioprine (Imuran), Chlorambucil
(Leukeran), Corticosteroids, Cyclosporine (Sandimmune), Mercaptopurine
(Purinethol) or Muromonab-CD3 monoclonal antibody (Orthoclone OKT3).
may increase the effects of Cytarabine on the heart and blood.
often increases the amount of uric acid in the blood. Probenecid
(Benemid) or Sulfinpyrazone (Anturane) are used to lower uric acid
levels and may need to be adjusted in patients taking cyclophosphamide.
may increase the effects and toxicity of Cocaine.
you schedule any medical tests, make sure that the doctor knows
that you are taking this drug. The results of some tests can be
affected by this medicine.
It is important that you drink extra fluids, you may have to drink
7 to 12 cups (3 quarts) of fluid a day so that you will pass more
urine. Empty your bladder frequently during the day and at least
once during the night. Cyclophosphamide is removed from the body
as your kidneys produce urine. If too much is present in the urine
or if the urine remains in the bladder for an extended period, it
can cause dangerous irritation.
may cause nausea, vomiting, and loss of appetite. It is vital that
you continue the medication even if you feel ill. Do not stop taking
this medicine unless you are told to by your doctor. There are medicines
that can relieve these symptoms if they become severe. If you vomit
after taking a dose of cyclophosphamide, check with your doctor
to decide whether to take the dose again or to wait until the next
with your health care provider immediately if you develop a cough
or hoarseness, fever or chills, lower back or side pain, painful
or difficult urination or, in women, if you miss a menstrual period.
you are being treated high doses of this medication or are on long-term
treatment tell your doctor immediately if you discover blood in
your urine, or experience dizziness, confusion, or agitation. Accelerated
or irregular heartbeat, joint pain, shortness of breath, swelling
of your feet or lower legs and unusual tiredness or weakness are
other signs that need to be communicated to the doctor as soon as
this treatment will result in dark-colored, tarry stools or bloody
stools, pinpoint red spots on your skin, unusual bleeding or bruising,
frequent urination, redness, swelling, or pain at site of injection,
sores in your mouth or on your lips, sudden shortness of breath,
unusual thirst or a yellowish tinge to your skin or in the
white of your eyes. These may be indications of serious side effects
and should be reported to the doctor at once.
serious side effects that usually go away during the course of the
treatment are a darkening ( not yellowing) of the skin and fingernails,
loss of appetite, nausea or vomiting, diarrhea or stomach pain,
flushing or redness of your face, headache, increased sweating,
skin rash, hives, or itching and swollen lips. Unless these become
exteremly uncomfortable, there is no need to get immediaite attention.
You should, of course, let the doctor know at your next appointment
that you are experienecing or did experience side effects.
can cause a temporary loss of hair in some people. Normal hair should
grow back, although the new hair might be a slightly different color
the treatment is complete you may still have some side effects.
Check with your doctor immediately if you notice blood in your urine
or severe lower back pain. You may have side effects that are not
listed. If you notice any unusual effects, check with your doctor.
you notice any other side effects, check with your doctor.
(CTX, CytoxanŽ, NeosarŽ, Procytox)
to Drug Index
is intended as reference and not as medical advice. All treatment
decisions should be made with your team of medical professionals
and prescriptions must be given by your doctor. See